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Une liste complète des conditions et des médicaments susceptibles de prolonger l'intervalle QT, et de provoquer des torsades de pointes (TdP) et le syndrome du QT long (LQTS) est présentée ci-dessous. En ce qui concerne les médicaments, le risque de prolongation du QT et de TdP varie considérablement selon la liste, mais tend à être assez similaire au sein d'une même classe de médicaments. Bien que le risque de TdP soit bien défini pour bon nombre de ces agents, beaucoup sont classés comme prolongateurs du QT uniquement en fonction de leur classe médicamenteuse ou de leurs effets pharmacodynamiques présumés. Nous fournissons une recherche directe sur PubMed pour chaque médicament et recommandons au lecteur d'utiliser ce lien pour évaluer la littérature.
Conditions médicales
| Catégorie | Condition |
|---|---|
| Conditions congénitales | Syndrome de Jervell et Lange-Nielsen |
| Syndrome de Romano-Ward | |
| Syndrome du QT long congénital idiopathique (LQTS) | |
| Troubles métaboliques | Hypokaliémie |
| Hypomagnésémie | |
| Hypocalcémie | |
| Jeûne | |
| Anorexie mentale | |
| Régimes protéinés liquides | |
| Hypothyroïdie | |
| Bradyarythmie | [Bradycardie sinusale](https://cardiovasc.fr/topic/bradycardie-sinusale-ecg-causes-traitement/) |
| [Dysfonctionnement du nœud sinusal](https://cardiovasc.fr/topic/dysfonctionnement-du-n%c5%93ud-sinusal-snd-syndrome-du-sinus-malade-sss/) | |
| Blocs AV |
Médicaments
| Drug | Brands | TdP Risk | Class | Clinical Use | Drugbank Description | Pubmed Record | DrugBank Record |
|---|---|---|---|---|---|---|---|
| Abarelix | Plenaxis | Classified as QT prolonging drug in DrugBank. No data on QT prolongation or risk of torsade de pointes in PubMed. | GnRH Antagonist | Cancer (prostate) | Synthetic décapeptide antagonist to gonadotropin-releasing hormone (GnRH). | [PubMed search Abarelix](http://www.ncbi.nlm.nih.gov/pubmed/?term=Abarelix+AND+(%22QT%22+OR+Torsad*)) | [DrugBank search Abarelix](https://go.drugbank.com/drugs/DB00106) |
| Abexinostat | None | Classified as QT prolonging drug in DrugBank. No data on QT prolongation or risk of torsade de pointes in PubMed. | Abexinostat has been used in trials studying the treatment of sarcoma, lymphoma, leukemia, lymphocytic, and Hodgkin disease, among others. It is a novel, broad-spectrum hydroxamic acid-based inhibitor of histone deacetylase… | [PubMed search Abexinostat](http://www.ncbi.nlm.nih.gov/pubmed/?term=Abexinostat+AND+(%22QT%22+OR+Torsad*)) | [DrugBank search Abexinostat](https://go.drugbank.com/drugs/DB12565) | ||
| Abiraterone | Zytiga, Abiratas, Abretone, Abirapro | Several cases of QT prolongation and torsade de pointes reported to the FDA in postmarketing studies. | Anti-androgen | Cancer (prostate) | Abiraterone is an antiandrogen used in the treatment of prostate cancer. | [PubMed search Abiraterone](http://www.ncbi.nlm.nih.gov/pubmed/?term=Abiraterone+AND+(%22QT%22+OR+Torsad*)) | DrugBank search Abiraterone |
| Aceprometazine | None | Classified as QT prolonging drug in DrugBank. No data on QT prolongation or risk of torsade de pointes in PubMed. | Drug with neuroleptic and antihistamine properties. | Sleep disorder | Aceprometazine is often used in combination with meprobamate for the treatment of sleep disorders. | [PubMed search Aceprometazine](http://www.ncbi.nlm.nih.gov/pubmed/?term=Aceprometazine+AND+(%22QT%22+OR+Torsad*)) | [DrugBank search Aceprometazine](https://go.drugbank.com/drugs/DB01615) |
| Acetyldigoxin | Classified as QT prolonging drug in DrugBank. No data on QT prolongation or risk of torsade de pointes in PubMed. | [PubMed search Acetyldigoxin](http://www.ncbi.nlm.nih.gov/pubmed/?term=Acetyldigoxin+AND+(%22QT%22+OR+Torsad*)) | [DrugBank search Acetyldigoxin](https://go.drugbank.com/drugs/DB13691) | ||||
| Aclarubicin | Aclarubicin | Several cases of QT prolongation and [ventricular fibrillation](https://cardiovasc.fr/topic/fibrillation-ventriculaire-activit%c3%a9-%c3%a9lectrique-sans-pouls-arr%c3%aat-cardiaque-soudain/) have been reported. See PubMed link. | [PubMed search Aclarubicin](http://www.ncbi.nlm.nih.gov/pubmed/?term=Aclarubicin+AND+(%22QT%22+OR+Torsad*)) | DrugBank search Aclarubicin | |||
| Acrivastine | QT prolongation has been described (see PubMed link). | An antihistamine agent used for the symptomatic relief of seasonal allergic rhinitis, rhinorrhea, pruritus, lacrimation, and nasal congestion. | [PubMed search Acrivastine](http://www.ncbi.nlm.nih.gov/pubmed/?term=Acrivastine+AND+(%22QT%22+OR+Torsad*)) | [DrugBank search Acrivastine](https://go.drugbank.com/drugs/DB09488) | |||
| Ajmaline | Ajimalin | Few cases with torsade de pointes described (see PubMed link). | Class IA antiarrhythmic | Arrhythmias | An antiarrhythmic used to manage several tachycardias. | [PubMed search Ajmaline](http://www.ncbi.nlm.nih.gov/pubmed/?term=Ajmaline+AND+(%22QT%22+OR+Torsad*)) | DrugBank search Ajmaline |
| Albuterol (Salbutamol) | Proventil, Ventolin, Ventolin-HFA, Accuneb, Combivent, Vospire-ER, ProAir HFA, Duoneb | Low risk | Bronchodilator | Asthma | Beta-2 adrenergic receptor agonist used to treat asthma, bronchitis, COPD, as well as prevent exercise-induced bronchospasms | PubMed search Albuterol (salbutamol) | DrugBank search Albuterol (salbutamol) |
| Alfuzosin | Uroxatral | Low to moderate risk | Alpha-1 adrenergic blocker | Benign prostatic hyperplasia | An alpha-1 adrenergic antagonist used in the symptomatic management of benign prostatic hypertrophy (BPH). | PubMed search Alfuzosin | DrugBank search Alfuzosin |
| Alimemazine | Panectyl | Classified as QT prolonging drug in Drugbank | An antihistamine agent used to prevent and relieve allergic conditions which cause pruritus and other allergic skin conditions, including urticaria. | PubMed search Alimemazine | DrugBank search Alimemazine | ||
| Alimemazine (Trimeprazine) | Panectyl | Low to moderate risk | Antihistamine | Allergic reactions | PubMed search Alimemazine (Trimeprazine) | DrugBank search Alimemazine (Trimeprazine) | |
| Amantadine | Symmetrel, Symadine, Gocovri, Osmolex | Low to moderate risk | Antiviral | Viral infection (Influenza), Parkinson’s disease | A medication used to treat dyskinesia in Parkinson’s patients receiving levodopa, as well as extrapyramidal side effects of medications. | PubMed search Amantadine | DrugBank search Amantadine |
| Amifampridine | Firdapse, Ruzurgi | Classified as QT prolonging drug. No cases described in PubMed (see link). Presumably low risk. | A voltage-gated potassium channel blocker used to treat Lambert-Eaton myasthenic syndrome. | PubMed search Amifampridine | DrugBank search Amifampridine | ||
| Amiodarone | Cordarone, Pacerone, Nexterone | Frequently causes non-significant QT prolongation. Rarely causes torsade de pointes. Low risk in patients without propensity for QT prolongation. | Class III Antiarrhythmic | Arrhythmia | A class III antiarrhythmic indicated for the treatment of ventricular premature beats, ventricular tachycardia and ventricular fibrillation. | PubMed search Amiodarone | DrugBank search Amiodarone |
| Amisulpride | Barhemsys, Solian, Supitac, Soltus, Amitrex, Amazeo | Low to moderate risk (with IV use) | Antiemetic, Antipsychotic | Nausea and vomiting, postoperative | Dopamine D2 receptor antagonist used in the treatment of acute and chronic schizophrenia, and in the prevention and treatment of postoperative nausea and vomiting in adults. | PubMed search Amisulpride | DrugBank search Amisulpride |
| Amitriptyline | Elavil, Tryptomer, Tryptizol, Laroxyl, Saroten, Sarotex Lentizol, Endep | Amitriptyline has been reported to induce long QT syndrome and Brugada syndrome (see PubMed link). | Antidepressant, Tricyclic | Depression | A tricyclic antidepressant indicated in the treatment of depressive illness, either endogenous or psychotic, and to relieve depression-associated anxiety. | PubMed search Amitriptyline | DrugBank search Amitriptyline |
| Amodiaquine | Data on amodiaquine are scarce, although transient effects on cardiac electrophysiology (QT interval prolongation and sinus bradycardia) have been observed (see PubMed link). | Antimalarial drug. | Antimalarial drug. | Antimalarial drug. | PubMed search Amodiaquine | DrugBank search Amodiaquine | |
| Amoxapine | Amoxapine | Amoxapine has been linked to cases of QT prolongation, acute heart failure, and sudden death (See PubMed links) | A tricyclic antidepressant used in the treatment of neurotic or reactive depressive disorders and endogenous or psychotic depression. | PubMed search Amoxapine | DrugBank search Amoxapine | ||
| Amphetamine (Amfetamine) | Adderal-XR, Dexedrine, Dextroamp, Adderall, Adzenys, Dyanavel, Evekeo, Mydayis | Moderate risk. | CNS stimulant | ADHD | CNS stimulant and sympathomimetic agent indicated for the treatment of Attention Deficit Hyperactivity Disorder (ADHD). | PubMed search Amphetamine (Amfetamine) | DrugBank search Amphetamine (Amfetamine) |
| Amphotericin B | Fungilin, Fungizone, Abelcet, AmBisome, Fungisome, Amphocil, Amphotec | Several cases of QT prolongation and torsade de pointes described (see PubMed link). | Antifungal | Fungal infection | Antifungal used in neutropenic patients, cryptococcal meningitis in HIV infection, fungal infections, and leishmaniasis. | PubMed search Amphotericin B | DrugBank search Amphotericin B |
| Amsacrine (Acridinyl anisidide) | Amsidine | Classified as QT prolonging drug | Antineoplastic Agent | Cancer (Acute Lymphoblastic Leukemia) | PubMed search Amsacrine (Acridinyl anisidide) | DrugBank search Amsacrine (Acridinyl anisidide) | |
| Anagrelide | Agrylin, Xagrid | Low to moderate risk | Phosphodiesterase 3 inhibitor | Thrombocythemia | A platelet-reducing agent used to treat thrombocythemia, and its related complications, secondary to myeloproliferative neoplasms. | PubMed search Anagrelide | DrugBank search Anagrelide |
| Anisodamine | Classified as QT prolonging drug | Anisodamine has been investigated for the treatment of intestinal diseases. | PubMed search Anisodamine | DrugBank search Anisodamine | |||
| Antazoline | Classified as QT prolonging drug | An antihistamine agent used for the symptomatic treatment of nasal congestion and allergic conjunctivitis. | PubMed search Antazoline | DrugBank search Antazoline | |||
| Apalutamide | Erleada | Classified as QT prolonging drug | Nonsteroidal antiandrogen | Cancer (prostate) | PubMed search Apalutamide | DrugBank search Apalutamide | |
| Apomorphine | Apokyn, Ixense, Spontane, Uprima | Low to moderate risk | Dopamine agonist | Parkinson’s disease | A morphine derivative D2 dopamine agonist used to treat hypomobile « off » episodes of advanced Parkinson’s disease. | PubMed search Apomorphine | DrugBank search Apomorphine |
| Aranidipine | Classified as QT prolonging drug | Aranidipine has been used for many years to treat angina pectoris and hypertension. | PubMed search Aranidipine | DrugBank search Aranidipine | |||
| Arformoterol | Brovana | Low risk | Bronchodilator | Asthma, COPD | A beta-2 adrenergic agonist and bronchodilator used for long-term, symptomatic treatment of reversible bronchoconstriction in patients with chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema. | PubMed search Arformoterol | DrugBank search Arformoterol |
| Aripiprazole | Abilify, Aripiprex | Classified as QT prolonging drug | Antipsychotic, atypical | Schizophrenia, depression (adjunct) | An atypical antipsychotic used in the treatment of a wide variety of mood and psychotic disorders, such as schizophrenia, bipolar I, major depressive disorder, irritability associated with autism, and Tourette’s syndrome. | PubMed search Aripiprazole | DrugBank search Aripiprazole |
| Aripiprazole lauroxil | Classified as QT prolonging drug | An antipsychotic used to treat schizophrenia in adults. | PubMed search Aripiprazole lauroxil | DrugBank search Aripiprazole lauroxil | |||
| Arsenic trioxide | Trisenox | High risk | Anti-cancer | Cancer (leukemia) | A chemotherapeutic agent used in the treatment of refractory or relapsed acute promyelocytic leukemia in patients with prior retinoid and anthracycline chemotherapy. | PubMed search Arsenic trioxide | DrugBank search Arsenic trioxide |
| Artemether | Classified as QT prolonging drug | An antimalarial agent used in combination with lumefantrine for the treatment of acute uncomplicated malaria caused by Plasmodium falciparum. | PubMed search Artemether | DrugBank search Artemether | |||
| Artemether Lumefantrine | Coartem | Low risk | Antimalarial | Malaria | PubMed search Artemether Lumefantrine | DrugBank search Artemether Lumefantrine | |
| Artenimol / Piperaquine | Eurartesim | Moderate risk | Antimalarial | Malaria | PubMed search Artenimol / Piperaquine | DrugBank search Artenimol / Piperaquine | |
| Asenapine | Saphris, Sycrest | Low to moderate risk | Antipsychotic, atypical | Schizophrenia | An atypical antipsychotic used to treat patients with bipolar I disorder and patients with schizophrenia. | PubMed search Asenapine | DrugBank search Asenapine |
| Astemizole | Hismanal | Classified as QT prolonging drug | Antihistamine | Allergic rhinitis | A second-generation antihistamine used to treat allergy symptoms. | PubMed search Astemizole | DrugBank search Astemizole |
| Atazanavir | Reyataz, Evotaz | Classified as QT prolonging drug | Antiviral | Viral infection (HIV/AIDS) | An antiviral protease inhibitor used in combination with other antiretrovirals for the treatment of HIV. | PubMed search Atazanavir | DrugBank search Atazanavir |
| Atomoxetine | Strattera | Low to moderate risk | CNS stimulant | ADHD | A selective norepinephrine reuptake inhibitor (SNRI) used in the management of Attention Deficit Hyperactivity Disorder (ADHD). | PubMed search Atomoxetine | DrugBank search Atomoxetine |
| Azatadine | Classified as QT prolonging drug | An H1 receptor antagonist used to treat perennial and allergic rhinitis as well as eustachian tube congestion. | PubMed search Azatadine | DrugBank search Azatadine | |||
| Azimilide | Classified as QT prolonging drug | Investigated for use/treatment in arrhythmia and atrial fibrillation. | PubMed search Azimilide | DrugBank search Azimilide | |||
| Azithromycin | Zithromax, Zmax | Moderate risk | Antibiotic | Bacterial infection | A macrolide antibiotic used to treat a variety of bacterial infections. | PubMed search Azithromycin | DrugBank search Azithromycin |
| Bedaquiline | Sirturo | High risk | Antibiotic | Tuberculosis, Multi-drug resistant | A diarylquinoline antimycobacterial used in combination with other antibacterials to treat pulmonary multidrug-resistant tuberculosis (MDR-TB). | PubMed search Bedaquiline | DrugBank search Bedaquiline |
| Bendamustine | Treanda, Treakisym, Ribomustin, Levact | Classified as QT prolonging drug | Anti-cancer | Cancer (Leukemia, lymphoma) | PubMed search Bendamustine | DrugBank search Bendamustine | |
| Bendroflumethiazide / Bendrofluazide | Aprinox, Corzide | Classified as QT prolonging drug | Diuretic, thiazide | Hypertension, diuresis | PubMed search Bendroflumethiazide / Bendrofluazide | DrugBank search Bendroflumethiazide / Bendrofluazide | |
| Benzatropine | Classified as QT prolonging drug | An anticholinergic drug used to treat Parkinson’s disease (PD) and extrapyramidal symptoms, except tardive dyskinesia. | PubMed search Benzatropine | DrugBank search Benzatropine | |||
| Benzphetamine | Didrex, Recede | Classified as QT prolonging drug | Obesity | PubMed search Benzphetamine | DrugBank search Benzphetamine | ||
| Bepridil | Vascor | High risk | Antianginal | Angina Pectoris (heart pain) | For the treatment of hypertension, and chronic stable angina (classic effort-associated angina). | PubMed search Bepridil | DrugBank search Bepridil |
| Berotralstat | Classified as QT prolonging drug | An inhibitor of plasma kallikrein used for prophylaxis of angioedema attacks in patients with hereditary angioedema. | PubMed search Berotralstat | DrugBank search Berotralstat | |||
| Besifloxacin | Classified as QT prolonging drug | A fluoroquinolone antibiotic agent used for the treatment of bacterial conjunctivitis. | PubMed search Besifloxacin | DrugBank search Besifloxacin | |||
| Betrixaban | Bevyxxa | Classified as QT prolonging drug | Anticoagulant | Anticoagulant | PubMed search Betrixaban | DrugBank search Betrixaban | |
| Bicalutamide | Casodex | Classified as QT prolonging drug | Anti-androgen | Cancer (prostate) | PubMed search Bicalutamide | DrugBank search Bicalutamide | |
| Bilastine | Blexten | Classified as QT prolonging drug | Antihistamines | Antihistamines | PubMed search Bilastine | DrugBank search Bilastine | |
| Bortezomib | Velcade, Bortecad | Classified as QT prolonging drug | Proteasome inhibitor | Cancer (multiple myeloma, lymphoma) | A proteasome inhibitor used to treat multiple myeloma in patients who have not been successfully treated with at least two previous therapies. | PubMed search Bortezomib | DrugBank search Bortezomib |
| Bosutinib | Bosulif | Low risk | Anti-cancer | Cancer (leukemia) | PubMed search Bosutinib | DrugBank search Bosutinib | |
| Buclizine | Classified as QT prolonging drug | An antihistamine and antiemetic drug for the treatment of allergy symptoms and prevention of nausea and vomiting. | PubMed search Buclizine | DrugBank search Buclizine | |||
| Bunaftine | Classified as QT prolonging drug | Not Annotated | PubMed search Bunaftine | DrugBank search Bunaftine | |||
| Bupranolol | Classified as QT prolonging drug | Used to manage hypertension and tachycardia. Also used to treat glaucoma. | PubMed search Bupranolol | DrugBank search Bupranolol | |||
| Buprenorphine | Butrans, Belbuca, Bunavail, Buprenex, Subutex, Suboxone, Zubsolv | Low risk | Opioid agonist | Narcotic dependence, pain | PubMed search Buprenorphine | DrugBank search Buprenorphine | |
| Buserelin | Classified as QT prolonging drug | An LHRH agonist used for the palliative treatment of hormone-dependent advanced carcinoma of the prostate gland in males and treatment of endometriosis in females. | PubMed search Buserelin | DrugBank search Buserelin | |||
| Butriptyline | Classified as QT prolonging drug | Butriptyline is a tricyclic antidepressant which has been used in Europe since 1974. It is the isobutyl side chain homologue of amitriptyline. | PubMed search Butriptyline | DrugBank search Butriptyline | |||
| Cabozantinib | Cometriq | Classified as QT prolonging drug | Anti-cancer | Cancer (renal cell) | PubMed search Cabozantinib | DrugBank search Cabozantinib | |
| Capecitabine | Xeloda | Moderate risk | Anti-cancer | Cancer (GI, Breast) | PubMed search Capecitabine | DrugBank search Capecitabine | |
| Carbetocin | Pabal, Lonactene, Duratocin | Moderate risk | Uterotonic | Uterine atony | PubMed search Carbetocin | DrugBank search Carbetocin | |
| Cariporide | Classified as QT prolonging drug | Investigated for use/treatment in cardiac surgery. | PubMed search Cariporide | DrugBank search Cariporide | |||
| Ceritinib | Zykadia | Moderate risk | Anti-cancer | Cancer (Lung) | An antineoplastic kinase inhibitor used to treat anaplastic lymphoma kinase (ALK)-positive metastatic non-small cell lung cancer (NSCLC) in patients with inadequate clinical response or intolerance to crizotinib. | PubMed search Ceritinib | DrugBank search Ceritinib |
| Cesium Chloride | Energy Catalyst | Classified as QT prolonging drug | Toxin | Alternative therapy cancer | PubMed search Cesium Chloride | DrugBank search Cesium Chloride | |
| Chloral hydrate | Aquachloral, Novo-Chlorhydrate, Somnos, Noctec, Somnote | Classified as QT prolonging drug | Sedative | Sedation, insomnia | PubMed search Chloral hydrate | DrugBank search Chloral hydrate | |
| Chlorcyclizine | Classified as QT prolonging drug | Chlorcyclizine is a first-generation phenylpiperazine class antihistamine used to treat urticaria, rhinitis, pruritus, and other allergy symptoms. Chlorcyclizine also has some local anesthetic, anticholinergic, and antiserotonergic properties, and can… | PubMed search Chlorcyclizine | DrugBank search Chlorcyclizine | |||
| Chloroquine | Aralen | Moderate risk | Antimalarial | Malaria | An antimalarial drug used to treat susceptible infections with P. vivax, P. malariae, P. ovale, and P. falciparum. It is also used for second-line treatment for rheumatoid arthritis. | PubMed search Chloroquine | DrugBank search Chloroquine |
| Chlorpromazine | Thorazine, Largactil, Megaphen | High risk | Antipsychotic / Antiemetic | Psychosis, nausea, many others | A phenothiazine antipsychotic used to treat nausea, vomiting, preoperative anxiety, schizophrenia, bipolar disorder, and severe behavioral problems in children. | PubMed search Chlorpromazine | DrugBank search Chlorpromazine |
| Chlorprothixene | Truxal | Classified as QT prolonging drug | Antipsychotic | Schizophrenia | PubMed search Chlorprothixene | DrugBank search Chlorprothixene | |
| Cibenzoline | Classified as QT prolonging drug | Not Annotated | PubMed search Cibenzoline | DrugBank search Cibenzoline | |||
| Cicletanine | Classified as QT prolonging drug | Cicletanine is under investigation for the treatment of diabetes, hypokalemia, hyponatremia, and arterial hypertension. | PubMed search Cicletanine | DrugBank search Cicletanine | |||
| Cilostazol | Pletal | Classified as QT prolonging drug | Phosphodiesterase 3 inhibitor | Intermittent claudication | An antiplatelet agent and vasodilator used for the symptomatic relief of intermittent claudication. | PubMed search Cilostazol | DrugBank search Cilostazol |
| Cimetidine | Tagamet | Classified as QT prolonging drug | Antacid | Gastric hyperacidity, GERD | PubMed search Cimetidine | DrugBank search Cimetidine | |
| Cinoxacin | Classified as QT prolonging drug | For the treatment of initial and recurrent urinary tract infections in adults caused by the following susceptible microorganisms: Escherichia coli, Proteus mirabilis, Proteus vulgaris, Klebsiella species (including K. pneumoniae), and… | PubMed search Cinoxacin | DrugBank search Cinoxacin | |||
| Ciprofloxacin | Cipro, Cipro-XR, Neofloxin | Low to moderate risk | Antibiotic | Bacterial infection | A second-generation fluoroquinolone used to treat various susceptible bacterial infections. | PubMed search Ciprofloxacin | DrugBank search Ciprofloxacin |
| Cisapride | Propulsid | High risk | GI stimulant | Increase GI motility | A medication used to treat heartburn associated with GERD. | PubMed search Cisapride | DrugBank search Cisapride |
| Citalopram | Celexa, Cipramil | Moderate risk | Antidepressant, SSRI | Depression | A selective serotonin reuptake inhibitor (SSRI) used in the treatment of depression. | PubMed search Citalopram | DrugBank search Citalopram |
| Clarithromycin | Biaxin, Prevpac | Moderate risk | Antibiotic | Bacterial infection | A macrolide antibiotic used for the treatment of a wide variety of bacterial infections such as acute otitis, pharyngitis, tonsillitis, respiratory tract infections, uncomplicated skin infections, and Helicobacter pylori infection. | PubMed search Clarithromycin | DrugBank search Clarithromycin |
| Clemastine | Classified as QT prolonging drug | An antihistamine with sedative and anticholinergic effects used to treat the symptoms of allergic rhinitis. | PubMed search Clemastine | DrugBank search Clemastine | |||
| Clofazimine | Lamprene | Moderate risk | Antibiotic | Leprosy | PubMed search Clofazimine | DrugBank search Clofazimine | |
| Clomipramine | Anafranil | Moderate risk | Antidepressant, Tricyclic | Depression | A tricyclic antidepressant used in the treatment of obsessive-compulsive disorder and disorders with an obsessive-compulsive component, such as depression, schizophrenia, and Tourette’s disorder. | PubMed search Clomipramine | DrugBank search Clomipramine |
| Clotiapine | Clotiapine | Classified as QT prolonging drug | PubMed search Clotiapine | DrugBank search Clotiapine | |||
| Clozapine | Clozaril, Fazaclo, Versacloz | Moderate risk | Antipsychotic, atypical | Schizophrenia | An antipsychotic drug used in treatment-resistant schizophrenia and to decrease suicide risk in schizophrenic patients. | PubMed search Clozapine | DrugBank search Clozapine |
| Cobimetinib | Cotellic | Classified as QT prolonging drug | Anti-cancer | Cancer (Melanoma) | PubMed search Cobimetinib | DrugBank search Cobimetinib | |
| Cocaine | Cocaine | Low to moderate risk with topical use | Local anesthetic | Anesthesia (topical) | An ester local anesthetic used during diagnostic procedures and surgeries in or through the nasal cavities. | PubMed search Cocaine | DrugBank search Cocaine |
| Coumaphos | Classified as QT prolonging drug | This drug is a fat-soluble phosphorothioate agent that kills both insects and mites. It is non-volatile in nature and is well known by a variety of names as such a… | PubMed search Coumaphos | DrugBank search Coumaphos | |||
| Crizotinib | Xalkori | Moderate risk | Anti-cancer | Cancer (Non-small cell lung cancer, metastatic) | A receptor tyrosine kinase inhibitor used to treat metastatic non-small cell lung cancer (NSCLC) where the tumors have been confirmed to be anaplastic lymphoma kinase (ALK), or ROS1-positive. | PubMed search Crizotinib | <a href="https://go.drugbank.com/drugs
Mis à jour 9 avril 2025
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