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Fenoldopam
| Drug | Fenoldopam |
| Brand names | Corlopam® |
| Indications | Short-term management of hypertension, including hypertensive emergency. |
| Mechanism of action | • Systemic dopamine-1 (D1) receptor agonist. • Lowers blood pressure while maintaining or increasing kidney perfusion. |
| Effects | Dopamine-1 receptor agonists lower systemic blood pressure and increase renal perfusion. |
| Time to onset of action | 5 to 10 minutes |
| Duration of action | 30 to 60 minutes |
| Delivery | IV |
| Dose | Initial infusion dose: 0.1 μg/kg/minute IV. Titrated at 15-minute intervals. Maximum infusion dose: 1.6 μg/kg/minute |
| Adverse effects | Headache. Flushing. Tachycardia. Nausea. Hypokalemia. Increased intraocular pressure in patients with glaucoma. |
| Caution | Used cautiously in patients with glaucoma or increased intracranial pressure. |
